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A Magnetic Sensor Based on Poly(γ-Glutamic Acid)-Functionalized Iron Oxide Nanoparticles for Cr3+ Detection

Author(s):

Zhibo Yu, Liang Jia, Jianzhi Zhu, Mingwu Shen, Jingchao Li*, Jinting Jiu, Maoquan Li and Xiangyang Shi*   Pages 1 - 8 ( 8 )

Abstract:


Background: The highly sensitive and selective detection of Cr3+ is critical.

Objective: We report the development of poly(γ-glutamic acid) (γ-PGA)-functionalized iron oxide nanoparticles (γ-PGA-Fe3O4 NPs) as a magnetic nanosensor for magnetic resonance (MR) detection of trivalent chromium (Cr3+) in aqueous solution.

Methods: The γ-PGA-Fe3O4 NPs with a mean particle size of 7.3 nm, good colloidal stability and ultrahigh r2 relaxivity (326.8 mM−1s−1) were synthesized via a facile mild reduction approach in the presence of γ-PGA, and used for MR detection of Cr3+.

Results: Upon exposure to Cr3+, the γ-PGA-Fe3O4 NPs aggregated into nanoclusters as verified by dynamic light scattering due to the coordination of Cr3+ with γ-PGA side chain carboxyl groups, resulting in the decrease in their transverse relaxation time. This MR signal change enables detection of Cr3+ in a concentration range of 0.4-1 nM. We also show that the γ-PGA-Fe3O4 NPs have an excellent selectivity toward Cr3+ and a high recovery percentage of 83.8% or above.

Conclusion: This study thus demonstrates that the developed γ-PGA-Fe3O4 NPs may be used as a nanoprobe for MR sensing of Cr3+ in water environment.

Keywords:

Nanosensor, magnetic resonance sensing, relaxivity, iron oxide nanoparticles, Cr3+ ions, poly(γ-glutamic acid).

Affiliation:

Department of Interventional and Vascular Surgery, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, The Institute of Scientific and Industrial Research (ISIR), Osaka University, Osaka 5670047, Department of Interventional and Vascular Surgery, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072, Department of Interventional and Vascular Surgery, Shanghai Tenth People’s Hospital, Tongji University School of Medicine, Shanghai 200072



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