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Progress and Prospects in Translating Nanobiotechnology in Medical Theranostics

[ Vol. 16 , Issue. 5 ]

Author(s):

Amna Batool, Farid Menaa*, Bushra Uzair, Barkat Ali Khan and Bouzid Menaa   Pages 685 - 707 ( 23 )

Abstract:


The pace at which nanotheranostic technology for human disease is evolving has accelerated exponentially over the past five years. Nanotechnology is committed to utilizing the intrinsic properties of materials and structures at submicroscopic-scale measures. Indeed, there is generally a profound influence of reducing physical dimensions of particulates and devices on their physico-chemical characteristics, biological properties, and performance. The exploration of nature’s components to work effectively as nanoscaffolds or nanodevices represents a tremendous and growing interest in medicine for various applications (e.g., biosensing, tunable control and targeted drug release, tissue engineering). Several nanotheranostic approaches (i.e., diagnostic plus therapeutic using nanoscale) conferring unique features are constantly progressing and overcoming all the limitations of conventional medicines including specificity, efficacy, solubility, sensitivity, biodegradability, biocompatibility, stability, interactions at subcellular levels.

This review introduces two major aspects of nanotechnology as an innovative and challenging theranostic strategy or solution: (i) the most intriguing (bare and functionalized) nanomaterials with their respective advantages and drawbacks; (ii) the current and promising multifunctional “smart” nanodevices.

Keywords:

Nanotechnology, nanomedicine, nanotheranostics, nanoplatforms, nanodevices, nanomaterials, nanostructures, nanosystems, translational medicine, innovation.

Affiliation:

Department of Biosciences, COMSATS Institute of Information Technology (CIIT), Islamabad, Department of Nanomedicine, California Innovations Corporation, San Diego, CA, Department of Bioinformatics and Biotechnology, International Islamic University Islamabad, Department of Biological Sciences, Gomal University, Khyber Pakhtunkhwa, Department of Nanomedicine, California Innovations Corporation, San Diego, CA



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