Ying Zhang, Huigang Chen, Qingxia Wang and Jing Sun* Pages 112 - 120 ( 9 )
Background: Photodynamic therapy (PDT) has become a very promising and effective strategy for the treatment of cancers and other malignant diseases. In recent years, photosensitizers (PS) with aggregation-induced emission (AIE) property have attracted great attention.
Objective: A high-performance AIE-active PS, E- 1-allyl-3-(2-(5-(4-(diphenylamino)phenyl) thiophene- 2-yl)vinyl)quinoxalin-2 (1H)-one (SJ-1), was synthesized and its PDT effect was preliminarily tested in vitro.
Methods: SJ-1 was designed using a quinoxalinone scaffold as the core chromophore. It could selfassembled into AIE-active nanoparticles with a mean size of 155 nm in aqueous medium and show maximum emission at 633 nm.
Results: SJ-1 nanoparticles at a concentration of 20 µM showed effective reactive oxygen species (ROS) production and could induce almost 90% decrease of cell viability under laser irradiation in Hela and HT-29 cells, with negligible dark toxicity.
Conclusion: In vitro results indicated that SJ-1 may be a potential PS for PDT.
SJ-1, nanoparticles, photosensitizer, ROS, AIE, PDT.
Department of Pharmacy, the Second Hospital of Shandong University, Jinan, Department of Obstetrics and Gynecology, Zhucheng Maternity and Infant Hospital, Zhucheng, Department of Pharmacy, the Second Hospital of Shandong University, Jinan, Department of Pharmacy, the Second Hospital of Shandong University, Jinan