Ying Zhang, Huigang Chen, Qingxia Wang and Jing Sun* Pages 1 - 9 ( 9 )
Background: Photodynamic therapy (PDT) has become a very promising and effective strategy for treatment of cancers and other malignant diseases. Recent years, photosensitizers (PS) with aggregation-induced emission (AIE) property has attracted great attention.Objective: A high-performance AIE-active PS, E- 1-allyl-3-(2-(5-(4-(diphenylamino)phenyl)thiophene-2-yl)vinyl)quinoxalin-2 (1H)-one (SJ-1), was synthesized and its PDT effect was preliminarily tested in vitro. Results: SJ-1 was designed using a quinoxalinone scaffold as the core chromophore. It could self-assembled into AIE-active nanoparticles with a mean size of 155 nm in aqueous medium and show maximum emission at 633 nm. SJ-1 nanoparticles at concentration of 20 μM showed effective reactive oxygen species (ROS) production and could induce almost 90% decrease of cell viability under laser irradiation in Hela and HT-29 cells, with negligible dark toxicity. Conclusion: In vitro results indicated SJ-1 maybe a potential PS for PDT.
SJ-1, nanoparticles, photosensitizer, ROS, AIE, PDT
Department of Medical Administration, Second Hospital of Shandong University, Jinan, , Department of Obstetrics and Gynecology, Zhucheng Maternity and Infant Hospital, Zhucheng,, Department of Medical Administration, Second Hospital of Shandong University, Jinan, , Department of Medical Administration, Second Hospital of Shandong University, Jinan