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Flower-shaped Micro/nanostructures Based on AlOOH with Antimicrobial Activity Against E. coli

[ Vol. 15 , Issue. 5 ]

Author(s):

Olga Vladimirovna Bakina*, Elena Alekseevna Glazkova, Alexander Vasiljevich Pervikov and Natalia Valentinovna Svarovskaya   Pages 525 - 531 ( 7 )

Abstract:


Background: Flower-shaped micro/nanostructures containing adsorbent and antimicrobial agent within the same particle are a new generation of materials with considerable potential in the field of biomedicine.

Objective: Flower-shaped micro/nanostructures were fabricated by the reaction of Al/Cu, Al/Fe and Al/Zn bimetallic nanoparticles with water. Al/Cu, Al/Fe and Al/Zn nanoparticles were produced by the simultaneous electric explosion of a pair of the corresponding metal twisted wires (aluminum and copper, aluminum and iron or aluminum and zinc) in argon atmosphere. The synthesized bimetallic nanoparticles interact with water to form micro/nanostructures with flower-shaped morphology.

Methods: The properties of the obtained products were characterized by transmission electron microscopy, scanning electron microscopy, X-ray diffraction, energy dispersive X-ray spectroscopy, adsorption of nitrogen (BET method) and electrophoretic mobility. The antimicrobial activity of the micro/nanostructures against the bacteria Escherichia coli was studied. The toxicity of these micro/ nanostructures against the L 929 mouse fibroblast cell line was investigated.

Results: The micro/nanostructures showed biocidal activity against gram-negative bacteria. The micro/nanostructures AlOOH(Fe) have a low toxicity and can be used for drug delivery.

Conclusion: The micro/nanostructures with flower-shaped are good candidates for medical applications as antimicrobial and healing dressing components.

Keywords:

Bimetallic nanoparticles, flower-shaped, alumina nanosheets, cytotoxicity, antibacterial activity, electrical explosion of wire, micro/nanostructures.

Affiliation:

Institute of Strength Physics and Materials Sciences, Siberian Branch of the Russian Academy of Sciences, Tomsk, 634021, Institute of Strength Physics and Materials Sciences, Siberian Branch of the Russian Academy of Sciences, Tomsk, 634021, Institute of Strength Physics and Materials Sciences, Siberian Branch of the Russian Academy of Sciences, Tomsk, 634021, Institute of Strength Physics and Materials Sciences, Siberian Branch of the Russian Academy of Sciences, Tomsk, 634021

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