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The Protective Effects of Graphene Oxide Against the Stress from Organic Solvent by Covering Hela Cells

[ Vol. 15 , Issue. 4 ]

Author(s):

Haidi Gao, Jia-Hui Liu*, Victoria Arantza León Anchustegui, Yulin Chang, Jichuan Zhang and Yiyang Dong*   Pages 412 - 419 ( 8 )

Abstract:


Background: In recent years, new nanomaterials have received great attention due to their widespread use in agriculture, food safety and pharmacy. Among them, graphene and graphene oxide (GO) are emerging as promising nanomaterials, which may have far-reaching effects on pharmacy and health.

Objective: In this paper, the living Hela cells were covered by GO (Hela@GO) and the cell viability, reactive oxygen species, membrane integrity and apoptosis of them were compared with the control Hela cells, especially under the stress from four kinds of organic solvent, including dimethyl sulphoxide, ethanol, acetone, and glycerin.

Results: It was suggested that the GO may protect cells by covering the cells, keeping their membrane integrity, reducing the ROS and decreasing the apoptosis.

Conclusion: GO has attracted the tremendous attention of their bioapplications. In this research, the GO adhered to Hela cells. It was observed that the Hela@GO grew well. Besides, it was suggested that the GO would play a protective role to Hela cells against four organic solvents, by maintaining the cell membrane integrity, reducing ROS, and inhibiting the apoptosis.

Keywords:

Graphene oxide, an organic solvent, cytotoxicity, reactive oxygen species, synergistic effect, membrane integrity.

Affiliation:

Beijing University of Chemical Technology,Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology,Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, Beijing Key Laboratory of Bioprocess, College of Life Science and Technology, Beijing University of Chemical Technology, College of Materials Science and Engineering, Beijing University of Chemical Technology, Beijing Key Laboratory of Bioprocess, College of Life Science and Technology



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