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Nanoprecipitated Ethylcellulose-Curcumin Particles for Controlled Release and Enhanced Antioxidant Activity

[ Vol. 14 , Issue. 4 ]

Author(s):

Rajat Subhra Dutta, Lalhlenmawia Hauzel, Probin Kumar Roy, Pratap Kalita, Takhellambam Bidyapati Devi, Dhitashree Deka and Lalduhsanga Pachuau*   Pages 298 - 306 ( 9 )

Abstract:


Background: Polyphenolics such as curcumin suffer from low aqueous solubility and extensive first pass metabolism which resulted in reduced oral bioavailability. Nanoformulations are increasingly investigated to overcome these obstacles and enhance the bioavailability of these polyphenolic bioactives.

Objective: The objective of the present work is to develop a novel ethylcellulose based curcumin nano-delivery system for controlled release and enhanced antioxidant activities.

Method: Nanoparticles were prepared following a simple nanoprecipitation method. Preformulation study was conducted through DSC and FTIR spectroscopy which showed that both the drug and the polymer were compatible. The surface morphology, particle size distribution and zeta potential of the nanoparticles were also analyzed along with drug release mechanism and antioxidant activities.

Result: The Z-average (d) of the nanoparticle was found to be 472 nm and the particles were found to possess a negative zeta-potential. The aqueous dispersibility of curcumin was significantly improved by the nanoparticulate formulation. Sustained release for over 12 hours was achieved and the release mechanism was found to be Fickian diffusion.

Conclusions: Determination of DPPH and LPO inhibition activity indicates that the nanoparticulate formulation of curcumin resulted in significant enhancement of its antioxidant activities.

Keywords:

Curcumin, ethylcellulose nanoparticles, nanoprecipitation, dispersibility, antioxidant, Fickian diffusion.

Affiliation:

Department of Pharmacy, Regional Institute of Paramedical and Nursing Sciences, Aizawl, Mizoram, Department of Pharmacy, Regional Institute of Paramedical and Nursing Sciences, Aizawl, Mizoram, Department of Pharmacy, Regional Institute of Paramedical and Nursing Sciences, Aizawl, Mizoram, Department of Pharmacy, Regional Institute of Paramedical and Nursing Sciences, Aizawl, Mizoram, Department of Pharmacy, Regional Institute of Paramedical and Nursing Sciences, Aizawl, Mizoram, Department of Pharmacy, Regional Institute of Paramedical and Nursing Sciences, Aizawl, Mizoram, Department of Pharmaceutical Sciences, SSMP, Assam University, Silchar - 788011

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